What this calculator does
FIB-4 index (liver fibrosis) works out screens for advanced liver fibrosis risk from age plus a routine liver panel and platelet count. Enter your own figures above and the answer updates as you type: nothing is fixed in the code, so the result reflects exactly the numbers you supply.
The formula this calculator evaluates is printed under the tool and explained below, so you can check the working by hand or reuse it in a spreadsheet.
The formula
FormulaFIB-4 = (age × AST) / (platelets(10⁹/L) × √ALT)
The inputs explained
| Field | What to enter |
|---|---|
| Age (years) | A number, measured in years. Starts at 50. |
| AST (U/L) | A number, measured in U/L. Starts at 30. |
| ALT (U/L) | A number, measured in U/L. Starts at 30. |
| Platelet count (×10⁹/L) | A number, measured in ×10⁹/L. Starts at 250. |
Worked examples
Every figure in the tables below is produced by this page’s own calculator at build time, so the numbers and the tool always agree. Select any row to load that scenario.
How the answer changes with age
Every other input is held at the calculator’s starting values while age varies. Select any row to load that scenario into the calculator.
How the answer changes with age
| Age (years) | FIB-4 index | Reading | Source |
|---|---|---|---|
| 25 | 0.55 | Below 1.45: advanced fibrosis is unlikely | Sterling et al. (2006), Hepatology |
| 37.5 | 0.82 | Below 1.45: advanced fibrosis is unlikely | Sterling et al. (2006), Hepatology |
| 50 | 1.10 | Below 1.45: advanced fibrosis is unlikely | Sterling et al. (2006), Hepatology |
| 75 | 1.64 | 1.45 - 3.25: indeterminate, further testing is often used | Sterling et al. (2006), Hepatology |
| 100 | 2.19 | 1.45 - 3.25: indeterminate, further testing is often used | Sterling et al. (2006), Hepatology |
| 150 | 3.29 | Above 3.25: advanced fibrosis is more likely | Sterling et al. (2006), Hepatology |